Welcome to Our Lab

csbl_logo miniThe Computational Systems Biology Lab (CSBL) in the Department of Biochemistry and Molecular Biology at the University of Georgia consists of scientists with highly diversified training background, ranging from biochemistry, computational chemistry, molecular biology, biophysics, physics to computer science, statistics and mathematics. Our common interests are in development of computational tools for solving biological problems. Our work ranges from construction of mathematical/statistical models to development of algorithms to code implementation to applications of computational tools to solve various bio-data analysis and modeling problems. Learn more about our research.

Cancer Bioinformatics published by Springer

The latest book by CSBL PI Dr. Ying Xu, along with co-authors Dr. J. David Puett and former lab member Dr. Juan Cui, Cancer Bioinformatics provides a framework for computational researchers studying the basics of cancer through comparative analyses of omic data. Read more here and see a review of the book here.

CSBL Journal Club

The dates for Fall Semester Journal Club for CSBL are:

Journal Club:
Date: every other Tuesday starting September, 2020
Time: 3:00-4:00pm
Venue: Davison Life Sciences Building, Room B116A
Hosted by: Yi Zhou (contact for any further information)


All Publications

Most Cited Paper

AD Williams, E Portelius, I Kheterpal, JT Guo, KD Cook, Y Xu, R Wetzel, Mapping Aβ amyloid fibril secondary structure using scanning proline mutagenesis, Journal of Molecular Biology, 335 (3), 833-842

Newest Paper on Cancer Research

Chi Zhang, Sha Cao, Bryan P. Toole, and Ying Xu, Cancer may be a pathway to cell survival under persistent hypoxia and elevated ROS: A model for solid-cancer initiation and early development, International Journal of Cancer, 2014, doi: 10.1002/ijc.28975

Newest Paper on Biofuels Research

C Zhou, Q Ma, X Mao, B Liu, Y Yin, Y Xu, New Insights into Clostridia Through Comparative Analyses of Their 40 Genomes, BioEnergy Research, 1-12

Newest Paper on Software Tools

Mao X1, Ma Q, Zhou C, Chen X, Zhang H, Yang J, Mao F, Lai W, Xu Y, DOOR 2.0: presenting operons and their functions through dynamic and integrated views, Nucleic Acids Research, 2014 Jan, doi: 10.1093/nar/gkt1048.


Our collaborators

University of Connecticut
Jilin University

More on Our Research

Meet our lab members

Cancer Computational and Systems Biology We are interested in developing integrated computational and omic techniques for (a) identification of biomarkers for a number of human cancers, detetable through analyses of serum/urine samples, and (b) understanding the relationships between molecular signatures and cancer formation & development. Our work involves microarray gene expression data generation and analyses, comparative genome analyses and analyses of other experimental data.

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Computational Study of Plant Cell-wall Synthesis Genes and Pathways We are interested in developing computational prediction and analysis techniques for inference of genes involved in cell wall synthesis in plants and regulatory elements of these genes & their relevant biochemical pathways. Our work currently involves prediction and analyses of protein-protein interactins relevant to cell wall synthesis, prediction of Golgi-residing proteins, bi-clustering analyses of microarray gene expression data and co-evolutionary analyses of cell-wall synthesis genes.

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Principal Investigator

Ying Founder
Ying Xu, Ph.D. Regents-GRA Eminent Scholar Chair and Professor Department of Biochemistry and Molecular Biology Ying Xu is a computational biologist with current research interests in cancer systems biology and microbial bioinformatics. He is a professor and endowed chair in computational biology and bioinformatics in the Department of Biochemistry and Molecular Biology and also adjunct professor in the departments of computer science and statistics, University of Georgia. Originally trained as a computer scientist with a Ph.D. degree from the University of Colorado at Boulder in 1991, he is currently studying fundamental biology problems using computer and statistics as tools. He has published over 300 research articles and five books in bioinformatics and computational biology.

Biofuels Research

Yu Shang
Yu Shang

Graduate Student

Fei Square
Fei Ji

Graduate Student

Xin Chen

Graduate Student

Qin Square
Qin Ma

Assistant Research Scientist

Cancer Research

Tao Tao

Graduate student

Hao Wu

Professor, Beijing Institute of Technology


Professor, Inner Mongolia University of Science and Technology

Jianzhen Xu

Professor, Shantou University Medical College

Tianci Song

Graduate Student

Yan Xia

Physician, The First Hospital Of Jilin University

Li Pang
Li Pang

Physician, The First Hospital Of Jilin University

Xiwen Zhu

Graduate Student

Jingyu Yang

Professor,Lanzhou Jiaotong University

Wei Du
Wei Du

Graduate Student

Ning Dong
Ning Dong

Physician, The First Hospital Of Jilin University

Huiyan Sun
Huiyan Sun

Graduate Student